Affiliations
Research Associate, Monell Chemical Senses Center
Education
Ph.D., Neuroscience, The Jikei University School of Medicine (Tokyo, Japan)
M.D., St. Marianna University School of Medicine (Kanagawa, Japan)
Laboratory Of
Dr. Johannes Reisert
Research Summary
My research involves understanding the mechanisms of adaptation in olfactory sensory neurons to an odorous stimulus and the factors involved in homeostatic regeneration of the olfactory epithelium. I will be studying the first step of olfactory perception in order to investigate the pathophysiology of olfactory dysfunction in the periphery. I am using electrophysiological as well as cell biological approaches to address these questions. Over the course working as a physician-scientist with a specialization in otorhinolaryngology, I am also interested in ENT-related medical research.
Keywords
olfaction, electro-olfactogram, electrophysiology, signal transduction, olfactory dysfunction
Representative Publications
Yamaguchi T, Nakamura R, Kuboki A, Otori N. (2022) Clinical study of skill assessment based on time sequential measurement changes. Sci Rep. 22;12(1):6638. doi: 10.1038/s41598-022-10502-7.
Kikuta S, Kuboki A, Yamasoba T. (2021) Protective effect of insulin in mouse nasal mucus against olfactory epithelium injury. Front Neural Circuits. 15:803769. doi: 10.3389/fncir.2021.803769.
Kuboki A, Kikuta S, Otori N, Kojima H, Matsumoto I, Reisert J, Yamasoba T. (2021) Insulin-dependent maturation of newly generated olfactory sensory neurons after injury. eNeuro. 19;8(3):ENEURO.0168-21.2021.
Kuboki A, Kanaya H, Nakayama T, Konno W, Goto K, Nakajima I, Kashiwagi T, Hirabayashi H, Haruna SI. (2019) Prognostic value of C-reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy. Head Neck. 41(5): 1342-1350.
Sugino T, Nakamura R, Kuboki A, Honda O, Yamamoto M, Otori N. (2019) Comparative analysis of surgical processes for image-guided endoscopic sinus surgery. Int J Comput Assist Radiol Surg. 14(1): 93-104. doi: 10.1007/s11548-018-1855-y.
Kuboki A, Kikuchi S, Asaka D, Onda N, Nakayama T, Kojima H, Otori N. (2018) Nasal silicone splints and quilting sutures using a septum stitch device following septoplasty: a prospective comparative study. Eur Arch Otorhinolaryngol. 275(7): 1803-1809.
Kikuta S, Matsumoto Y, Kuboki A, Nakayama T, Asaka D, et al. (2016) Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder. Sci Rep. doi: 10. 1038/srep35361.
