Affiliations
Member Emeritus, Monell Chemical Senses Center
Senior Lecturer, Princeton Neuroscience Institute, Princeton University
Education
Ph.D., Biology; University of Pennsylvania
Research Summary
I studied odor information processing and memory storage using biological, computational and electronic approaches. At Monell, my lab studied biological olfaction using mammalian systems whose central odor processing networks reliably compute complex predictive relationships between odor stimuli and rewards. We recorded in vivo from mitral cells in the mouse olfactory bulb during odor discrimination and odor learning to identify learning-induced alterations in mitral cell activity. In vitro studies of a slice preparation of the olfactory bulb allowed us to test biophysical models of mitral cell plasticity. Patch and optical recording methods were utilized to understand the role of oscillatory dynamics and neurogenesis in odor recognition and memory storage. Computational methods generated biophysically-based network models of the olfactory system to identify general design principles. With collaborators in electronic olfaction we worked on developing new odor sensor arrays, sensor circuits and algorithms to develop a new generation of electronic olfactory systems able to solve hard problems like finding buried land mines or contribute to disease diagnosis.
Keywords
systems neuroscience, behavioral neuroscience, learning and memory, olfactory information processing, neuronal biophysics, olfactometry, optical recording, elctronic olfaction, electronic chemosensors, neurophysiological methods, odor sensing for disease diagnosis, neuroethology
Representative Publications
Reisert, J., Golden, G., Dibattista, M., Gelperin, A. (2020) Dynamics of odor sampling strategies in mice. PLOS ONE, in press.
Ambrosini, A, and Gelperin, A. (2020) Reproducible quantitative stimulation allows new analysis of crayfish muscle receptor organ responses. Journal of Undergraduate Neuroscience Education, in press.
Gelperin, A. (2019) Current trends in invertebrate neuroscience. In: The Oxford Handbook of Invertebrate Neurobiology, Ed. J. Byrne, Oxford University Press, pp.1-57. Gelperin A. (2017) Methods in rodent olfactory cognition. In: Olfactory Receptors – Methods and Protocols. Ed. Fabio M. Simoes de Souza and Gabriela Antunes, Springer Nature Pub. Co., 229-238.
Gelperin, A. (2014) Comparative chemosensory cognition. Frontiers in Behavioral Neuroscience, 8, 190.
Gelperin, A. (2013) Associate memory mechanisms in terrestial slugs and snails. In: Benjamen, P.; Menzel, R. (Eds.) Invertebrate Learning and Memory: Handbook of Behavioral Neuroscience. Academic Press. pp. 280-290.
Reisert, J.; Golden, G.J.; Matsumura, K.; Smear, M.; Rinberg, D.; Gelperin, A. (2013) Comparing thoracic and intra-nasal pressure transients to monitor active odor sampling during odor-guided decision making in the mouse. Journal of Neuroscience Methods, 221, 8-14.
