Affiliations
Senior Research Associate, Monell Chemical Senses Center
Education
Ph.D., Animal Genetics; Rheinische Friedrich-Wilhelms-University of Bonn, Germany
Laboratory Of
Dr. Danielle Reed
Research Summary
My research focuses on the genetic mapping and genomic analysis of taste and taste relevant complex traits in mice and humans. The ultimate goal of my studies is to identify genes that are involved in taste perception, alcohol consumption, obesity, taste and smell disorder. To achieve this goal, we create consomic and congenic mouse strains, take advantage of a large long-term UK Biobank and other long-term clinic data sets, and use state-of-the-art molecular technologies (scRNASeq and scATACSeq) and advanced data science tools.
Keywords
taste perception, ingestive behavior, taste and smell disorder, genetic mapping, genomic analysis
Representative Publications
Lin C, Tordoff MG, Li X, Bosak NP, Inoue M, Ishiwatari Y, Chen L, Beauchamp GK, Bachmanov AA, Reed DR. (2021). Genetic controls of Tas1r3-independent sucrose consumption in mice. Genetic controls of Tas1r3-independent sucrose consumption in mice. Mamm Genome, (2):70-93. PMID: 33710367
Lin C, Inoue M, Li X, Bosak NP, Ishiwatari Y, Tordoff MG, Beauchamp GK, Bachmanov AA, Reed DR. (2021). Genetics of mouse behavioral and peripheral neural responses to sucrose. Mamm Genome, (2):51-69. PMID: 33713179
Lin C, Colquitt L, Wise P, Breslin PAS, Rawson NE, Genovese F, Maina I, Joseph P, Fomuso L, Slade L, Brooks D, Miclo A, Hayes JE, Sullo A, Reed DR. (2020). Studies of human twins reveal genetic variation that affects dietary fat perception. Chem Senses, 45(6):467-81. PMID: 32516399
Hwang LD, Lin C, Gharahkhani P, Cuellar-Partida G, Ong JS, An J, Gordon SD, Zhu G, MacGregor S, Lawlor DA, Breslin PAS, Wright MJ, Martin NG, Reed DR. (2019). New Insight Into Human Sweet Taste: A Genome-Wide Association Study of the Perception and Intake of Sweet Substances. Am J Clin Nutr, 109(6):1724-1737. PMID: 31005972
Shaw L, Mansfield C, Colquitt L, Lin C, Ferreira J, Emmetsberger J, Reed DR. (2018). Personalized expression of bitter ‘taste’ receptors in human skin. PLoS One, 13(10):e0205322. PMID: 30332676
Douglas JE, Lin C, Mansfield CJ, Arayata CJ, Cowart BJ, Spielman AI, Adappa ND, Palmer JN, Cohen NA, Reed DR. (2018). Tissue-dependent expression of bitter receptor TAS2R38 mRNA. Chem Senses, 44(1):33-40. PMID: 30351347
Lin C, Fesi BD, Marquis M, Bosak NP, Lysenko A, Koshnevisan MA, Duke FF, Theodorides ML, Nelson TM, McDaniel AH, Avigdor M, Arayata CJ, Shaw L, Bachmanov AA, Reed DR. (2018). Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2. Mamm Genome, PMID: 29737391
Lin C, Fesi BD, Marquis M, Bosak NP, Lysenko A, Koshnevisan MA, Duke FF, Theodorides ML, Nelson TM, McDaniel AH, Avigdor M, Arayata CJ, Shaw L, Bachmanov AA, Reed DR. (2017). Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains. PLoS One, 12(12):e0188972. PMID:29194435
Lin C, Fesi BD, Marquis M, Bosak NP, Theodorides ML, Avidgdor M, McDaniel AH, Duke FF, Lysenko A, Koshnevisan A, Gantick BR, Arayata CJ, Nelson TM, Bachmanov A, Reed DR. (2015). Body composition QTLs identified in intercross populations are reproducible in consomic mouse strains. PLoS ONE, 10(11):e0141494, PMID: 26551037
Lin C, Theodorides ML, McDaniel AH, Tordoff MG, Zhang Q, et al. (2013). QTL Analysis of Dietary Obesity in C57BL/6byj X 129P3/J F2 Mice: Diet- and Sex-Dependent Effects. PLoS ONE, 8(7): e68776. PMID: 23922663
