Danielle R. Reed

Faculty

Affiliations

Associate Director, Monell Chemical Senses Center
Member, Monell Chemical Senses Center

Education

Ph.D., Psychology; Yale University

Research Summary

I am interested in why people differ in their sense of taste and smell and how inborn genotype contributes to these differences. For instance, there are medicines that taste extremely bitter to some people whereas others perceive them as tasteless or nearly so. These differences are due in part to genetic variation in the bitter taste receptor genes and these genotype differences can differ based on ancestry. Recently we have been studying person-to-person differences in the loss of taste and smell as a result of COVID-19 as a part of the Global Consortium for Chemosensory Research.

Keywords

sweet, genetics, taste, smell, obesity, genomics, genetic mapping

Representative Publications

Mainland, J. D., Barlow, L. A., Munger, S. D., Millar, S. E., Vergara, M. N., Jiang, P., Schwob, J. E., Goldstein, B. J., Boye, S. E., Martens, J. R., Leopold, D. A., Bartoshuk, L. M., Doty, R. L., Hummel, T., Pinto, J. M., Trimmer, C., Kelly, C., Pribitkin, E. A., Reed, D. R. (2020). Identifying Treatments For Taste And Smell Disorders: Gaps And Opportunities. Chemical Senses, Bjaa038. Advance Online Publication. https://doi.org/10.1093/Chemse/Bjaa038

Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, Joseph PV, Reed DR. Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19 positive patients compared to subjective methods: a systematic review and meta-analysis. MEDRXIV 2020.07.04.20145870; doi: https://doi.org/10.1101/2020.07.04.20145870

Gerkin RC, Ohla K, Veldhuizen Mg, Joseph PV, Kelly Ce, Bakke AJ, Steele KE, Farruggia MC, Pellegrino R, Pepino My, Bouysset C, Soler GM, Pereda-Loth V, Dibattista M, Cooper KW, Croijmans I, Di Pizio A, Ozdener MH, Fjaeldstad AW, Lin C, Sandell MA, Singh PB, Brindha VE, Olsson SB, Saraiva LR, Ahuja G, Alwashahi MK, Bhutani S, D’errico A, Fornazieri MA, Golebiowski J, Hwang LD, Öztürk L, Roura E, Spinelli S, Whitcroft Kl, Faraji F, Fischmeister Fps, Heinbockel T, Hsieh JW, Huart C, Konstantinidis I, Menini A, Morini G, Olofsson JK, Philpott CM, Pierron D, Shields VDC, Voznessenskaya VV, Albayay J, Altundag A, Bensafi M, Bock MA, Calcinoni O, Fredborg W, Laudamiel C, Lim J, Lundström JN, Macchi A, Meyer P, Moein ST Santamaría E, Sengupta D, Domínguez Pp, Yanik H, Boesveldt S, De Groot Jhb, Dinnella C, Freiherr J, Laktionova T, Mariño S, Monteleone E, Nunez-Parra A, Abdulrahman O, Ritchie M, Thomas-Danguin T, Walsh-Messinger J, Al Abri R, Alizadeh R, Bignon E, Cantone E, Cecchini MP, Chen J, Guàrdia MD, Hoover KC, Karni N, Navarro M, Nolden AA, Mazal PP, Rowan NR, Sarabi-Jamab A, Archer NS, Chen B, Di Valerio EA, Feeney El, Frasnelli J, Hannum M, Hopkins C, Klein H, Mignot C, Mucignat C, Ning Y, Ozturk EE, Peng M, Saatci O, Sell Ea, Yan Ch, Alfaro R, Cecchetto C, Coureaud G, Herriman Rd, Justice JM, Kaushik PK, Koyama S, Overdevest JB, Pirastu N, Ramirez VA, Roberts Sc, Smith BC, Cao H, Wang H, Balungwe P, Baguma M, Hummel T, Hayes JE, Reed DR, Niv MY, Munger SD, Parma V. Recent Smell Loss is The Best Predictor of Covid-19: A Preregistered, Cross-Sectional Study. Medrxiv [Preprint]. 2020 Jul 26:2020.07.22.20157263. doi: 10.1101/2020.07.22.20157263. PMID: 32743605; PMCID: PMC7386529.

Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, Cooper KW, Bouysset C, Pirastu N, Dibattista M, Kaur R, Liuzza MT, Pepino MY, Schöpf V, Pereda-Loth V, Olsson SB, Gerkin RC, Rohlfs Domínguez P, Albayay J, Farruggia MC, Bhutani S, Fjaeldstad AW, Kumar R, Menini A, Bensafi M, Sandell M, Konstantinidis I, Di Pizio A, Genovese F, Öztürk L, Thomas-Danguin T, Frasnelli J, Boesveldt S, Saatci Ö, Saraiva LR, Lin C, Golebiowski J, Dar Hwang L, Ozdener MH, Guàrdia MD, Laudamiel C, Ritchie M, Havlícek J, Pierron D, Roura E, Navarro M, Nolden AA, Lim J, Whitcroft KL, Colquitt LR, Ferdenzi C, Brindha EV, Altundag A, Macchi A, Nunez-Parra A, Patel ZM, Fiorucci S, Philpott CM, Smith BC, Lundström JN, Mucignat C, Parker JK, van den Brink M, Schmuker M, Fischmeister FPS, Heinbockel T, Shields VDC, Faraji F, Santamaría E, Fredborg WEA, Morini G, Olofsson JK, Jalessi M, Karni N, D’Errico A, Alizadeh R, Pellegrino R, Meyer P, Huart C, Chen B, Soler GM, Alwashahi MK, Welge-Lüssen A, Freiherr J, de Groot JHB, Klein H, Okamoto M, Singh PB, Hsieh JW, Reed DR, Hummel T, Munger SD, Hayes JE; GCCR Group Author. More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chem Senses. 2020 Jun 20:bjaa041. doi: 10.1093/chemse/bjaa041. Epub ahead of print. PMID: 32564071; PMCID: PMC7337664.

Reed DR, Mainland JD, Arayata CJ. Sensory nutrition: The role of taste in the reviews of commercial food products. Physiol Behav. 2019 Jun 12;209:112579. doi: 10.1016/j.physbeh.2019.112579. PubMed PMID: 31199938.

Hwang LD, Lin C, Gharahkhani P, Cuellar-Partida G, Ong JS, An J, Gordon SD, Zhu G, MacGregor S, Lawlor DA, Breslin PAS, Wright MJ, Martin NG, Reed DR. New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. Am J Clin Nutr. 2019 Jun 1;109(6):1724-1737. doi: 10.1093/ajcn/nqz043. PubMed PMID: 31005972; PubMed Central PMCID: PMC6537940.

Douglas JE, Lin C, Mansfield CJ, Arayata CJ, Cowart BJ, Spielman AI, Adappa ND, Palmer JN, Cohen NA, Reed DR. Tissue-Dependent Expression of Bitter Receptor TAS2R38 mRNA. Chem Senses. 2019 Jan 1;44(1):33-40. doi: 10.1093/chemse/bjy066. PubMed PMID: 30351347; PubMed Central PMCID: PMC6295798.

Shaw L, Mansfield C, Colquitt L, Lin C, Ferreira J, Emmetsberger J, Reed DR. Personalized expression of bitter ‘taste’ receptors in human skin. PLoS One. 2018 Oct 17;13(10):e0205322. doi: 10.1371/journal.pone.0205322. eCollection 2018. PubMed PMID: 30332676; PubMed Central PMCID: PMC6192714.

Hwang LD, Gharahkhani P, Breslin PAS, Gordon SD, Zhu G, Martin NG, Reed DR, Wright MJ. Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste. BMC Genomics. 2018 Sep 17;19(1):678. doi: 10.1186/s12864-018-5058-2. PubMed PMID: 30223776; PubMed Central PMCID: PMC6142396.

Douglas JE, Mansfield CJ, Arayata CJ, Cowart BJ, Colquitt LR, Maina IW, Blasetti MT, Cohen NA, Reed DR. Taste Exam: A Brief and Validated Test. J Vis Exp. 2018 Aug 17;(138). doi: 10.3791/56705. PubMed PMID: 30176005; PubMed Central PMCID: PMC6128106.

Lin C, Fesi BD, Marquis M, Bosak NP, Lysenko A, Koshnevisan MA, Duke FF, Theodorides ML, Nelson TM, McDaniel AH, Avigdor M, Arayata CJ, Shaw L, Bachmanov AA, Reed DR. Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2. Mamm Genome. 2018 Jun;29(5-6):325-343. doi: 10.1007/s00335-018-9746-7. Epub 2018 May 8. PubMed PMID: 29737391.

Lin C, Fesi BD, Marquis M, Bosak NP, Lysenko A, Koshnevisan MA, Duke FF, Theodorides ML, Nelson TM, McDaniel AH, Avigdor M, Arayata CJ, Shaw L, Bachmanov AA, Reed DR. Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains. PLoS One. 2017 Dec 1;12(12):e0188972. doi: 10.1371/journal.pone.0188972. eCollection 2017. PubMed PMID: 29194435; PubMed Central PMCID: PMC5711020.

Danielle Reed

Contact Information

(267) 519-4915
reed@monell.org