Danielle R. Reed

Faculty

Affiliations

Associate Director, Monell Chemical Senses Center
Member, Monell Chemical Senses Center

Education

Ph.D., Psychology; Yale University

Research Summary

I am interested in why people differ in their sense of taste and smell and how inborn genotype contributes to these differences. For instance, there are medicines that taste extremely bitter to some people whereas others perceive them as tasteless or nearly so. These differences are due in part to genetic variation in the bitter taste receptor genes and these genotype differences can differ based on ancestry. Recently we have been studying person-to-person differences in the loss of taste and smell as a result of COVID-19 as a part of the Global Consortium for Chemosensory Research.

Keywords

sweet, genetics, taste, smell, obesity, genomics, genetic mapping

Representative Publications

Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis.
Hannum ME, Koch RJ, Ramirez VA, Marks SS, Toskala AK, Herriman RD, Lin C, Joseph PV, Reed DR. Chem Senses. 2022 Jan 1;47:bjac001. doi: 10.1093/chemse/bjac001.
PMID: 35171979

The Adaptive Olfactory Measure of Threshold (ArOMa-T): A rapid test of olfactory function.
Weir EM, Hannum ME, Reed DR, Joseph PV, Munger SD, Hayes JE, Gerkin RC.
medRxiv. 2022 Mar 10:2022.03.08.22272086. doi: 10.1101/2022.03.08.22272086. Preprint.
PMID: 35313597

Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis.
Arnold MC, Poonia S, Colquitt L, Lin C, Civantos A, Kohanski M, Adappa ND, Palmer JN, Reed DR, Cohen NA. Int Forum Allergy Rhinol. 2022 Jan 6. doi: 10.1002/alr.22960. Online ahead of print.
PMID: 34990088

Massively collaborative crowdsourced research on COVID19 and the chemical senses: Insights and outcomes.
Weir EM, Reed DR, Pepino MY, Veldhuizen MG, Hayes JE.
Food Qual Prefer. 2022 Apr;97:104483. doi: 10.1016/j.foodqual.2021.104483. Epub 2021 Nov 26. PMID: 34848930

SCENTinel 1.0: Development of a Rapid Test to Screen for Smell Loss.
Parma V, Hannum ME, O’Leary M, Pellegrino R, Rawson NE, Reed DR, Dalton PH.
Chem Senses. 2021 Jan 1;46:bjab012. doi: 10.1093/chemse/bjab012. PMID: 33773496

Genetics of mouse behavioral and peripheral neural responses to sucrose.
Lin C, Inoue M, Li X, Bosak NP, Ishiwatari Y, Tordoff MG, Beauchamp GK, Bachmanov AA, Reed DR. Mamm Genome. 2021 Apr;32(2):51-69. doi: 10.1007/s00335-021-09858-4. Epub 2021 Mar 13. PMID: 33713179

Genetic controls of Tas1r3-independent sucrose consumption in mice.
Lin C, Tordoff MG, Li X, Bosak NP, Inoue M, Ishiwatari Y, Chen L, Beauchamp GK, Bachmanov AA, Reed DR. Mamm Genome. 2021 Apr;32(2):70-93. doi: 10.1007/s00335-021-09860-w. Epub 2021 Mar 12.
PMID: 33710367

Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms.
Gerkin RC, Ohla K, Veldhuizen MG, Joseph PV, Kelly CE, Bakke AJ, Steele KE, Farruggia MC, Pellegrino R, Pepino MY, Bouysset C, Soler GM, Pereda-Loth V, Dibattista M, Cooper KW, Croijmans I, Di Pizio A, Ozdener MH, Fjaeldstad AW, Lin C, Sandell MA, Singh PB, Brindha VE, Olsson SB, Saraiva LR, Ahuja G, Alwashahi MK, Bhutani S, D’Errico A, Fornazieri MA, Golebiowski J, Dar Hwang L, Öztürk L, Roura E, Spinelli S, Whitcroft KL, Faraji F, Fischmeister FPS, Heinbockel T, Hsieh JW, Huart C, Konstantinidis I, Menini A, Morini G, Olofsson JK, Philpott CM, Pierron D, Shields VDC, Voznessenskaya VV, Albayay J, Altundag A, Bensafi M, Bock MA, Calcinoni O, Fredborg W, Laudamiel C, Lim J, Lundström JN, Macchi A, Meyer P, Moein ST, Santamaría E, Sengupta D, Rohlfs Dominguez P, Yanik H, Hummel T, Hayes JE, Reed DR, Niv MY, Munger SD, Parma V; GCCR Group Author. Chem Senses. 2021 Jan 1;46:bjaa081. doi: 10.1093/chemse/bjaa081. PMID: 33367502

Objective Sensory Testing Methods Reveal a Higher Prevalence of Olfactory Loss in COVID-19-Positive Patients Compared to Subjective Methods: A Systematic Review and Meta-Analysis.
Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, Joseph PV, Reed DR.
Chem Senses. 2020 Dec 5;45(9):865-874. doi: 10.1093/chemse/bjaa064.
PMID: 33245136

Cellular context of IL-33 expression dictates impact on anti-helminth immunity.
Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM, Li Hui Tan T, Kohanski MA, Bryce P, Lin C, Kambayashi T, Reed DR, Brown BL, Cohen NA, Herbert DR. Sci Immunol. 2020 Nov 13;5(53):eabc6259. doi: 10.1126/sciimmunol.abc6259. PMID: 33188058

Denatonium benzoate bitter taste perception in chronic rhinosinusitis subgroups.
Civantos AM, Maina IW, Arnold M, Lin C, Stevens EM, Tan LH, Gleeson PK, Colquitt LR, Cowart BJ, Bosso JV, Palmer JN, Adappa ND, Kohanski MA, Reed DR, Cohen NA.
Int Forum Allergy Rhinol. 2021 Jun;11(6):967-975. doi: 10.1002/alr.22687. Epub 2020 Sep 3.
PMID: 32885614

Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients.
Lin C, Civantos AM, Arnold M, Stevens EM, Cowart BJ, Colquitt LR, Mansfield C, Kennedy DW, Brooks SG, Workman AD, Blasetti MT, Kohanski MA, Doghramji L, Douglas JE, Maina IW, Palmer JN, Adappa ND, Reed DR, Cohen NA.
Int Forum Allergy Rhinol. 2021 May;11(5):857-865. doi: 10.1002/alr.22686. Epub 2020 Aug 26.
PMID: 32846055

Danielle Reed

Contact Information

(267) 519-4915
reed@monell.org