Member, Monell Chemical Senses Center
Ph.D., Physiology; University of Cambridge
My laboratory investigates one of the first steps in olfactory perception: the conversion of an odorous stimulus into a nerve signal. Olfactory receptor neurons located in the nose detect odorants and generate the electrical response, which is then conveyed to the brain for further processing. The focus of our research is to understand 1) how olfactory receptor neurons code odor signals of different odorants, 2) the cellular mechanisms that lead to the generation and termination of those responses and, 3) how the characteristics of odorant responses of olfactory receptor neurons drive behaviors. We use electrophysiological and cell imaging techniques, immunohistochemistry and behavioral approaches to address these questions.
olfaction, single cell electrophysiology, signal transduction, ion channels
Kuboki A, Kikuta S, Otori N, Kojima H, Matsumoto I, Reisert J, Yamasoba T. (2021). Insulin-Dependent Maturation of Newly Generated Olfactory Sensory Neurons after Injury. eNeuro, 8(3):ENEURO.0168-21.2021.
Reisert J, Golden GJ, Dibattista M & Gelperin A. (2020). Dynamics of odor sampling strategies in mice. PloS ONE 15, e0237756.
Reisert J & Reingruber J. (2019). Ca2+-activated Cl– current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons. Proc Natl Acad Sci USA 116, 1053-1058.
Dibattista M, Pifferi S, Boccaccio A, Menini A & Reisert J. (2017). The long tale of the calcium activated Cl– channels in olfactory transduction. Channels (Austin) 11, 399-414.
Dibattista M & Reisert J. (2016). The odorant receptor-dependent role of olfactory marker protein in olfactory receptor neurons. J Neurosci 36, 2995-3006.
Mainland JD, Lundstrom JN, Reisert J & Lowe G. (2014). From molecule to mind: an integrative perspective on odor intensity. Trends Neurosci 37, 443-454.