Affiliations
Postdoctoral Fellow, Monell Chemical Senses Center
Education
Ph.D., Biochemistry, Department of Korean medicine, Kyung-Hee University, South Korea
Laboratory Of
Dr. Hong Wang
Research Summary
COVID-19, a respiratory infection caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), affects millions of people and can cause chemosensory dysfunctions such as loss or distortion of taste and smell. My research interests include understanding the underlying mechanisms of chemosensory disorders caused by respiratory viruses and finding ways to care for and protect against taste and smell loss. Using clinical biopsies and in vitro and in vivo models, I investigate how chemosensory disorders, such as smell and taste loss, develop in patients and identify their molecular signatures. Our research may help patients who still have smell and/or taste loss by uncovering molecular mechanisms. Our study may reveal scientific clues for drug discovery of therapeutic agents for treating taste and smell disorders with minimal side effects.
Keywords
COVID-19, chemosensory disorder, chemosensory signaling, immune responses, sensory organoid
Representative Publications
Kang-Hoon Kim, Jubeen Yoon, Christian P. Macks, Han-Eol Park, Jihyun Youn, Jung-uk Lee, Minji An, Jongseong Park, Jaewon Ko, and Chang Ho Sohn (2023). Molecular decrowding by tissue expansion allows precise determination of the spatial distribution of synaptic proteins at a nanoscale by exTEM. ACS Nano, 17, 11, 9919-9937.
Kang-Hoon Kim, Ji Hoon Jung, Won-Seok Chung, Chang Hun Lee, Hyeung-Jin Jang (2021). Ferulic acid induces keratin 6α by inhibition of nuclear β-catenin accumulation and activation of Nrf2 on wound-induced inflammation. Biomedicine, 22;9(5)
Kang-Hoon Kim, Ye-Ji Park, Hyun-Jae Jang, Seung-Jae Lee, Soyoung Lee, Bong-Sik Yun, Seung Woong Lee and Mun-Chual Rho (2020). Rugosic acid A, derived from Rosa rugosa Thunb., is novel inhibitory agent for NF-κB and IL-6/STAT3 axis in acute lung injury model. Phytother Research, 2020, 1-11.
Hyun-Jae Jang*, Kang-Hoon Kim*, Eun-Jae Park, Jeong A Kang, Bong-Sik Yun, Seung-Jae Lee, Chan Sun Park, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho (2020). Anti-inflammatory activity of diterpenoids from Celastrus orbiculatus in lipopolysaccharide-stimulated RAW264.7 cells. J Immunol Research, 2020, 7207354.
Kang-Hoon Kim, Eun Young Bae, Hyun Goo Lim, Mi Heui Kim, Tae-Seok Oh, Seung Woong Lee (2020). Eleocharis kuroguwai Ohwi Ameliorates LPS-mediated Inflammation by Suppressing MAPKs Signaling. J Life Sci, 30, 5, 476-482.
Kang-Hoon Kim, Eun-Jae Park, Hyun-Jae Jang, Seung-Jae Lee, Chan Sun Park, Bong-Sik Yun, Seung Woong Lee#, & Mun-Chual Rho# (2019). 1-Carbomethoxy-b-carboline, derived from Portulaca oleacea L., ameliorates LPS-mediated inflammatory response associated with MAPK signaling and nuclear translocation of NF-kB. Molecules, 24, 22, 4042.
Alessandro Bertucci*, Kang-Hoon Kim*, Jinyoung Kang, Jonathan M. Zuidema, Seo Hyeon Lee, Ester J. Kwon, Dokyoung Kim, Stephen B. Howell, Francesco Ricci, Erkki Ruoslahti, Hyeung-Jin Jang#, and Michael J. Sailor# (2019). Tumor-targeting, microRNA-silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy. ACS Applied Materials & Interfaces, 11, 27, 23926-23937.
Kang-Hoon Kim, Jiyoung Park, In-Seung Lee, Yumi Kim, Eun Jin An, & Hyeung Jin Jang. (2018). Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-like peptide-1 via Bitter Taste Receptor Signaling. Frontiers in Pharmacol, 9, 1071, 1-13.
