Kevin Bolding

Faculty

Affiliations

Assistant Member, Monell Chemical Senses Center

Education

B.S., Genetics and Biochemistry, Texas A&M University
M.A., Behavioral Neuroscience, CU Boulder
Ph.D., Neural and Behavioral Science, SUNY Downstate

Research Summary

In the Bolding Lab, our goal is to discover fundamental rules and mechanisms that govern information storage and retrieval in neural systems. Our primary focus will be establishing the changes in neural circuit and population dynamics that correspond to odor recognition memory. To bring our understanding of this process to a new level of rigor we will apply quantitative statistical approaches to relate behavioral signatures of odor recognition to activity and plasticity in olfactory circuits. We will use in vivo electrophysiology and calcium imaging to capture the activity of large neural populations during olfactory experience, and we will apply cell-type specific perturbations of activity and plasticity to discover how specific circuit connections contribute.

Keywords

olfaction, quantitative behavioral analysis, in vivo electrophysiology, calcium imaging, optogenetics, systems neuroscience, behavioral neuroscience, neural coding, aging, memory, social recognition

Representative Publications

Bolding KA, Nagappan S, Han BX, Wang F, Franks KM. (2020) Recurrent Circuitry Is Required to Stabilize Piriform Cortex Odor Representations Across Brain States. eLife, 2020;9:e53125.

Bolding KA, Ferbinteanu J, Fox SE, Muller RU. (2019) Place Cell Firing Cannot Support Navigation Without Intact Septal Circuits. Hippocampus, 2019;10.1002/hipo.23136.

Bolding KA, Franks KM. (2018) Recurrent Cortical Circuits Implement Concentration-Invariant Odor Coding. Science, 2018;361(6407):eaat6904.

Stern M, Bolding KA, Abbott LF, Franks KM. (2018) A Transformation From Temporal to Ensemble Coding in a Model of Piriform Cortex. eLife, 2018;7:e34831.

Bolding KA, Franks KM. (2017) Complementary Codes for Odor Identity and Intensity in Olfactory Cortex. eLife, 2017;6:e22630.

Contact Information

kbolding@monell.org

Join Us!

The Bolding Lab is currently recruiting personnel, including technicians and postdocs:

  • The primary criteria are to be highly engaged by systems neuroscience research and have a strong interest in the questions our lab is pursuing.
  • Experience with large-scale in vivo electrophysiology, calcium imaging in freely-moving animals, quantitative behavior analysis, machine learning/statistics, computational modeling, and olfactometer design and operation is valued.