Affiliations
Assistant Member, Monell Chemical Senses Center
Education
B.S., Genetics and Biochemistry, Texas A&M University
M.A., Behavioral Neuroscience, CU Boulder
Ph.D., Neural and Behavioral Science, SUNY Downstate
Research Summary
In the Bolding Lab, our goal is to discover fundamental rules and mechanisms that govern information storage and retrieval in neural systems. Our primary focus will be establishing the changes in neural circuit and population dynamics that correspond to odor recognition memory. To bring our understanding of this process to a new level of rigor we will apply quantitative statistical approaches to relate behavioral signatures of odor recognition to activity and plasticity in olfactory circuits. We will use in vivo electrophysiology and calcium imaging to capture the activity of large neural populations during olfactory experience, and we will apply cell-type specific perturbations of activity and plasticity to discover how specific circuit connections contribute.
Keywords
olfaction, quantitative behavioral analysis, in vivo electrophysiology, calcium imaging, optogenetics, systems neuroscience, behavioral neuroscience, neural coding, aging, memory, social recognition
Representative Publications
Bolding KA, Nagappan S, Han BX, Wang F, Franks KM. (2020) Recurrent Circuitry Is Required to Stabilize Piriform Cortex Odor Representations Across Brain States. eLife, 2020;9:e53125.
Bolding KA, Ferbinteanu J, Fox SE, Muller RU. (2019) Place Cell Firing Cannot Support Navigation Without Intact Septal Circuits. Hippocampus, 2019;10.1002/hipo.23136.
Bolding KA, Franks KM. (2018) Recurrent Cortical Circuits Implement Concentration-Invariant Odor Coding. Science, 2018;361(6407):eaat6904.
Stern M, Bolding KA, Abbott LF, Franks KM. (2018) A Transformation From Temporal to Ensemble Coding in a Model of Piriform Cortex. eLife, 2018;7:e34831.
Bolding KA, Franks KM. (2017) Complementary Codes for Odor Identity and Intensity in Olfactory Cortex. eLife, 2017;6:e22630.
