M. Hakan Ozdener

Senior Research Associate

Affiliations

Senior Research Associate, Monell Chemical Senses Center

Education

M.D., Ondokuz Mayis University, Samsun, Turkey
Ph.D., Biochemistry; Ondokuz Mayis University, Samsun Turkey, -ICGEB, New Delhi India
MPH, (Public Health); Temple University

Laboratory Of

Dr. Robert Margolskee

Research Summary

My primary research focuses on the development of in vitro chemosensory cell culture systems for the study of chemosensory biology and disorders. I utilize chemosensory cells obtained from humans and from rodents to examine the factors involved in differentiation and maturation and to better understand how chemosensory receptor cells interact in their responses to stimuli. This work will enable us to develop and characterize novel tastant and new therapeutic targets to promote regeneration following injury from surgery, radiation, toxic exposures, or deterioration due to aging or neurodegenerative disease. My work also involves exploring the molecular mechanisms of taste transduction of novel and known taste molecules in mammalian taste cells utilizing molecular biology, biochemistry, and cell physiology techniques.

Keywords

taste cell, olfactory cells, development, cell culture, chemosensory cells, infection

Representative Publications

Ozdener, M.H.; Donadoni, M.; Cicalese, S.; Spielman, A.I.; Garcia-Blanco, A.; Gordon, J.; Sariyer, I.K. (2020) Zika virus infection in chemosensory cells. J Neurovirol. doi: 10.1007/s13365-020-00835-2. [Epub ahead of print]

Malik, B.; Elkaddi, N.; Turkistani, J.; Spielman, A.I.; Ozdener, M.H. (2019) Mammalian Taste Cells Express Functional Olfactory Receptors. Chemical Senses. 44, 289-301. doi: 10.1093/chemse/bjz019.

Murtaza, B.; Hichami, A.; Khan, A.S.; Shimpukade, B.; Ulven, T.; Ozdener, M.H.; Khan, N.A. (2019) Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice. Journal of Lipid Research. pii: jlr.RA119000142. doi: 10.1194/jlr.RA119000142.

Ozdener, M.H.; Ashby, R.D.; Jyotaki, M.; Elkaddi, N.; Spielman, A.I.; Bachmanov, A.A.; Solaiman, D.K. (2019) Sophorolipid Biosurfactants Activate Taste Receptor Type 1 Member 3ÔÇÉMediated Taste Responses and Block Responses to Bitter Taste In Vitro and In Vivo. Journal of Surfactants and Detergents. doi:10.1002/jsde.12246

Sariyer, I.K.; Gordon, J.; Burdo, T.H.; Wollebo, H.S.; Gianti, E.; Donadoni, M.; Bellizzi, A.; Cicalese, S.; Loomis, R.; Robinson, J.A.; Carnevale, V.; Steiner, J.; Ozdener, M.H.; Miller, A.D.; Amini, S.; Klein, M.L.; Khalili, K. (2019) Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine. Molecular Therapy. doi: 10.1016/j.ymthe.2019.10.006.

M. Hakan Ozdener

Contact Information

(267) 519-4824
hozdener@monell.org