Affiliations
Member Emeritus, Monell Chemical Senses Center
Education
Ph.D., Physiological Psychology; Princeton University
Research Summary
My research is directed at the bodily mechanisms that control eating behavior. The focus is on identifying those changes in energy metabolism that serve as signals controlling food intake and characterizing how these signals are detected and transmitted to the brain. This work has implications for understanding the relationship between energy intake and the development of obesity and for treating disturbances in food intake and appetite.
Keywords
appetite, energy metabolism, liver, obesity, feeding behavior
Representative Publications
Friedman M.I., T.I.A. Sørensen, G. Taubes, J. Lund, D.S. Ludwig. (2024) Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning. Obesity Reviews, https://doi.org/10.1111/obr.13795.
Friedman, M.I. and H. Ji. (2022) Limited defense of liver energy status in rats susceptible to diet-induced obesity. bioRxiv, https://doi.org/10.1101/2022.10.26.513713.
Ludwig, D.S., L.J. Aronne, A. Astrup, R. de Cabo, L.C. Cantley, M.I. Friedman, S.B. Heymsfield, J.D. Johnson, J.C. King, R.M. Krauss, D.E. Lieberman, G. Taubes, J.S. Volek, E.C. Westman, W.C. Willett, W.S. Yancy, C.B. Ebbeling. (2021) The carbohydrate-insulin model: a physiological perspective on the obesity pandemic. American Journal of Clinical Nutrition, https://doi.org/10.1093/ajcn/nqab270.
Friedman, M.I. (2008) Food intake: Control, regulation and the illusion of dysregulation. In: Appetite and Food Intake: Behavioral and Physiological Considerations. (R. Harris and R. Mattes, eds.), Boca Raton: CRC Press, pp. 1-19.
Friedman, M.I. (2007) Obesity and the hepatic control of feeding behavior. Drug News & Perspectives, http://dx.doi.org/10.1358/dnp.2007.20.9.1162243.
Friedman, M.I. (1997) An energy sensor for control of energy intake. Proceedings of the Nutrition Society, https://doi.org/10.1079/PNS19970008.
