Affiliations
Member Emeritus, Monell Chemical Senses Center
Education
Ph.D., Physiological Psychology; Princeton University
Research Summary
My research is directed at the bodily mechanisms that control eating behavior. The focus is on identifying those changes in energy metabolism that serve as signals controlling food intake and characterizing how these signals are detected and transmitted to the brain. This work has implications for understanding the relationship between energy intake and the development of obesity and for treating disturbances in food intake and appetite.
Keywords
appetite, energy metabolism, liver, obesity, feeding behavior
Representative Publications
Ludwig, D.S.; Aronne, L.J.; Astrup, A.; de Cabo, R.; Cantley, L.C.; Friedman, M.I.; et al. (2021) The carbohydrate-insulin model: a physiological perspective on the obesity pandemic. American Journal of Clinical Nutrition, 114, 1873–85.
Friedman, M.I.; Appel, S. (2019) Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men: A secondary analysis of energy expenditure and physical activity. PLoS ONE, 14, doi.org/10.1371/journal.pone.0222971.
Ludwig, D.S.; Friedman, M.I. (2014) Increasing adiposity: consequence or cause of overeating? JAMA, 311, 2167-2168.
Ji, H.; Friedman, M.I. (2008) Reduced hepatocyte fatty acid oxidation in outbred rats pre-screened for susceptibility to diet-induced obesity. International Journal of Obesity, 32, 1331-1334.
Friedman, M.I. (2008) Food intake: Control, regulation and the illusion of dysregulation. In: Harris, R.; Mattes, R. (Eds) Appetite and Food Intake: Behavioral and Physiological Considerations, Boca Raton: CRC Press, 1-19.
Friedman, M.I. (2007) Obesity and the hepatic control of feeding behavior. Drug News & Perspectives, 20, 573-578.
Ji, H.; Friedman, M.I. (2007) Reduced capacity for fatty acid oxidation in rats with inherited susceptibility to diet-induced obesity. Metabolism, 56, 1124-1130.
