Affiliations
Member, Monell Chemical Senses Center
Emeritus Director and President, Monell Chemical Senses Center
Adjunct Professor, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine
Education
M.D., Ph.D., Molecular Genetics; Johns Hopkins University
Research Summary
Dr. Margolskee’s long-standing research focus is on the molecular mechanisms of taste transduction, using molecular biology, biochemistry, transcriptomics, structural biology, electrophysiology and transgenesis to study the mechanisms of signal transduction in mammalian taste cells. His recent research is focused on caloric-sensing alternative sweet taste signaling and the functions of taste signaling proteins in extraoral cells.
Keywords
taste receptor, molecular biology, gastrointestinal chemosensation, transduction, taste signalling proteins, stem cells
Representative Publications
Zheng X, Zhu J, Liu J, Wang H, Qin Y, Jiang P, Xiao L, Gong T, Li Y, Peng X, Xu X, Cheng L, Huang L, Chen Q, Zhou X, Margolskee RF. (2022). Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4. Chem Senses, 47:bjac034. doi: 10.1093/chemse/bjac034. PMID: 36484118.
Breslin PAS, Izumi A, Tharp A, Ohkuri T, Yokoo Y, Flammer LJ, Rawson NE, and Margolskee RF. (2021). Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway. PLoS ONE 16(10): e0256989. https://doi.org/10.1371/journal.pone.0256989
Qin Y, Sukumaran SK, Margolskee RF. (2021). Nkx2-2 expressing taste cells in endoderm-derived taste papillae are committed to the type III lineage. Dev Biol, 477:232-240. doi: 10.1016/j.ydbio.2021.05.020. Epub 2021 Jun 5. PMID: 34097879.
Yoshida R, Margolskee RF, Ninomiya Y. (2021). Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells. J Neurochem, 158(2):233-245. doi: 10.1111/jnc.15268. Epub 2021 Feb 26. PMID: 33319361; PMCID: PMC8284875.
Wang Y, Zajac AL, Lei W, Christensen CM, Margolskee RF, Bouysset C, Golebiowski J, Zhao H, Fiorucci S, Jiang P. (2019). Metal Ions Activate the Human Taste Receptor TAS2R7. Chem Senses, 44, 339-347.
Zheng X, Tizzano M, Redding K, He J, Peng X, Jiang P, Xu X, Zhou X, Margolskee RF. (2019). Gingival solitary chemosensory cells are immune sentinels for periodontitis. Nat Commun, 10, 4496.
Du YW, Liu Q, Luo XC, Zhao DX, Xue JB, Feng P, Margolskee RF, Wang H, Huang L. (2018). Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model. J Vis Exp, (141), 10.3791/58668.
Qin Y, Sukumaran SK, Jyotaki M, Redding K, Jiang P, Margolskee RF. (2018). Gli3 is a negative regulator of Tas1r3-expressing taste cells. PLoS Genet, 14(2):e1007058. doi: 10.1371/journal.pgen.1007058. PMID: 29415007; PMCID: PMC5819828.
Lei W, Ren W, Ohmoto M, Urban JF Jr, Matsumoto I, Margolskee RF, Jiang P. (2018). Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci USA, 115, 5552-5557.
