Robert F. Margolskee



Director and President, Monell Chemical Senses Center
Adjunct Professor, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine


M.D., Ph.D., Molecular Genetics; Johns Hopkins University

Research Summary

Dr. Margolskee’s long-standing research focus is on the molecular mechanisms of taste transduction, utilizing molecular biology, biochemistry, transcriptomics, structural biology, electrophysiology and transgenesis to study the mechanisms of signal transduction in mammalian taste cells. More recently he has been studying the chemosensory functions of taste signaling proteins in gut endocrine cells and gingival innate immune cells. Other projects in the Margolskee lab focus on taste stem cells and endocrine/metabolic properties of taste cells.


taste receptor, molecular biology, gastrointestinal chemosensation, transduction, taste signalling proteins, endocrine function, stem cells

Representative Publications

Breslin PAS, Izumi A, Tharp A, Ohkuri T, Yokoo Y, Flammer LJ, Rawson NE, and Margolskee RF (2021) Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway. PLoS ONE 16(10): e0256989.

Erik Schwiebert, Yi Wang, Ranhui Xi, Katarzyna Choma, John Streiff, Linda J. Flammer, Natasha Rivers, Mehmet Hakan Ozdener, Robert F. Margolskee, Carol M. Christensen, Nancy E. Rawson, Peihua Jiang and Paul A. S. Breslin (2021) 6-Methylflavone blocks bitterness of tenofovir. Molecular Pharmacology 99 (5) 319-327;

Feng S, Achoute L, Margolskee RF, Jiang P, Wang H. (2020) Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids. Chem Senses, 45, 187-194.

Takai S, Watanabe Y, Sanematsu K, Yoshida R, Margolskee RF, Jiang P, Atsuta I, Koyano K, Ninomiya Y, Shigemura N. (2019) Effects of insulin signaling on mouse taste cell proliferation. PLoS One, 14, e0225190.

Wang Y, Zajac AL, Lei W, Christensen CM, Margolskee RF, Bouysset C, Golebiowski J, Zhao H, Fiorucci S, Jiang P. (2019) Metal Ions Activate the Human Taste Receptor TAS2R7. Chem Senses, 44, 339-347.

Zheng X, Tizzano M, Redding K, He J, Peng X, Jiang P, Xu X, Zhou X, Margolskee RF. (2019) Gingival solitary chemosensory cells are immune sentinels for periodontitis. Nat Commun, 10, 4496.

Du YW, Liu Q, Luo XC, Zhao DX, Xue JB, Feng P, Margolskee RF, Wang H, Huang L. (2018) Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model. J Vis Exp, (141), 10.3791/58668.

Feng P, Chai J, Yi H, Redding K, Margolskee RF, Huang L, Wang H. (2018) Aggravated gut inflammation in mice lacking the taste signaling protein α-gustducin. Brain Behav Immun, 71, 23-27.

Lei W, Ren W, Ohmoto M, Urban JF Jr, Matsumoto I, Margolskee RF, Jiang P. (2018) Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci U S A, 115, 5552-5557.

Robert Margolskee

Contact Information

(267) 519-4710