Research Associate, Monell Chemical Senses Center
Ph.D., Organic Chemistry; University of Pennsylvania
Dr. Bruce Kimball
Medical diagnosis through the body odor volatile metabolome has generally relied on one of two categories of analysis: odor analysis using a trained animal biosensor, or chemometric analysis using an electronic noes or GC-MS. Our lab has demonstrated that alterations of body odor that occur in response to inflammation could be detected by GC-MS utilized headspace analysis of biosamples, such as blood, saliva, sweat or urine. These identified volatile metabolomes may have potential as biomarkers that could be useful for diagnosing disease, so we are encouraged for the future of differential medical diagnosis by analysis of the body odor volatile metabolome.
body odor, medical diagnosis, GC-MS, volatile metabolome
Chaskes MB, Lee YE, Toskala E, Nyquist G, Rosen M, Kimball B, Rabinowitz M. (2022) Unique volatile metabolite signature of sinonasal inverted papilloma detectable in plasma and nasal secretions. IFAR. doi: /10.1002/alr.22984
Kane SA, Lee YE, Essler JL, Mallikarjun A, Preti G, Plymouth VL, Verta A, DeAngelo A, Otto CM. (2022) Canine discrimination of ovarian cancer through volatile organic compounds. Talanta. 250:123729. doi: 10.1016/j.talanta.2022.123729. PMID: 35839605